Articles

Childhood leukaemia may be preventable by exposure to infections in early life

BMJ Recent Articles - Mon, 05/21/2018 - 19:15
The more common form of childhood leukaemia is caused by a two stage process of genetic mutation and may be preventable, a leading expert in the disease has said.1Acute lymphoblastic leukaemia (ALL)...
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Margaret McCartney: Tech companies, healthcare, and a clash of cultures

BMJ Recent Articles - Mon, 05/21/2018 - 13:00
Facebook stands accused of misusing data on a grand scale. Millions of people’s information has been used in ways they didn’t fully expect or explicitly permit. This has been done most notably by...
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Autism spectrum disorder: advances in diagnosis and evaluation

BMJ Recent Articles - Mon, 05/21/2018 - 12:35
AbstractAutism spectrum disorder (ASD) has a variety of causes, and its clinical expression is generally associated with substantial disability throughout the lifespan. Recent advances have led to...
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Diagnostic accuracy of point-of-care natriuretic peptide testing for chronic heart failure in ambulatory care: systematic review and meta-analysis

BMJ Recent Articles - Mon, 05/21/2018 - 12:30
AbstractObjectiveTo assess the diagnostic accuracy of point-of-care natriuretic peptide tests in patients with chronic heart failure, with a focus on the ambulatory care setting.DesignSystematic...
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Women are under-represented in the Clinical Excellence Awards

BMJ Recent Articles - Mon, 05/21/2018 - 11:55
Appleby discusses the gender pay gap in the NHS.1 A major source of gender pay disparity for NHS consultants arises from the Clinical Excellence Awards. Women are one third of the consultant...
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Assisted dying: Guernsey rejects proposal to move towards legalisation

BMJ Recent Articles - Mon, 05/21/2018 - 11:35
A majority of politicians in Guernsey have voted against a proposal that would have approved moves towards legalising assisted dying—a change that would have created the first such regime in the...
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Society’s expectations of women contribute to pay gap

BMJ Recent Articles - Mon, 05/21/2018 - 08:55
I was interested to read about the ongoing gender pay gap in the NHS.1 Those of us who work in it may not be surprised. Statistics published last year showed that female doctors earned 34% less than...
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The Grand Social Experiment at 70: Who is really paying for your NHS?

BMJ Recent Articles - Mon, 05/21/2018 - 08:25
Whenever a reader points out that the UK (or Australia) spends less on healthcare as a percentage of gross domestic product than most countries of the Organisation for Economic Cooperation and...
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Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses.

Latest Pubmed articles about Swine flu - Wed, 05/16/2018 - 19:00
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Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses.

Sci Rep. 2018 May 10;8(1):7474

Authors: Alymova IV, McCullers JA, Kamal RP, Vogel P, Green AM, Gansebom S, York IA

Abstract
Specific residues of influenza A virus (IAV) PB1-F2 proteins may enhance inflammation or cytotoxicity. In a series of studies, we evaluated the function of these virulence-associated residues in the context of different IAV subtypes in mice. Here, we demonstrate that, as with the previously assessed pandemic 1968 (H3N2) IAV, PB1-F2 inflammatory residues increase the virulence of H1N1 IAV, suggesting that this effect might be a universal feature. Combining both inflammatory and cytotoxic residues in PB1-F2 enhanced virulence further, compared to either motif alone. Residues from these virulent motifs have been present in natural isolates from human seasonal IAV of all subtypes, but there has been a trend toward a gradual reduction in the number of virulent residues over time. However, human IAV of swine and avian origin tend to have more virulent residues than do the human-adapted seasonal strains, raising the possibility that donation of PB1 segments from these zoonotic viruses may increase the severity of some seasonal human strains. Our data suggest the value of surveillance of virulent residues in both human and animal IAV to predict the severity of influenza season.

PMID: 29749408 [PubMed - in process]

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