CCGs consider bringing in minimum waiting times

BMJ Recent Articles - Fri, 11/17/2017 - 16:31
The Royal College of Surgeons has urged clinical commissioning groups to drop plans to introduce minimum waiting times for non-urgent procedures.Several CCGs, including Trafford and four in...
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Woman who rejected breast cancer diagnosis may undergo surgery without her consent

BMJ Recent Articles - Fri, 11/17/2017 - 15:26
A 66 year old woman with paranoid schizophrenia may be put under general anaesthetic and have surgery for breast cancer without her consent, a High Court judge has ruled.1Mr Justice Keehan declared...
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New guideline will put 30 million more Americans in high BP group

BMJ Recent Articles - Fri, 11/17/2017 - 14:50
New US guidelines will bring the number of US adults considered to have high blood pressure from 72 million to 103 million.The new guidance, published by the American Heart Association and American...
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Tackling the health burden of air pollution in South Asia

BMJ Recent Articles - Fri, 11/17/2017 - 13:41
Air pollution exposure is the second most important risk factor for ill health in South Asia, contributing to between 13% and 21.7% of all deaths and approximately 58 million disability adjusted life...
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Risk of AMD has decreased over the past few generations, study finds

BMJ Recent Articles - Fri, 11/17/2017 - 13:31
The risk of age related macular degeneration (AMD) has decreased by more than 60% in each subsequent generation of people born throughout the twentieth century, a large US study has reported.1“This...
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Campaigners vow to fight on after report finds no link between hormone test and birth defects

BMJ Recent Articles - Fri, 11/17/2017 - 13:11
Campaigners have called for a judicial review after a UK government report found that hormone based pregnancy tests (HPTs) given to women in the 1960s and 1970s did not cause birth defects.An expert...
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Pigs with Severe Combined Immunodeficiency Are Impaired in Controlling Influenza A Virus Infection.

Latest Pubmed articles about Swine flu - Tue, 11/14/2017 - 20:00
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Pigs with Severe Combined Immunodeficiency Are Impaired in Controlling Influenza A Virus Infection.

J Innate Immun. 2017;9(2):193-202

Authors: Rajao DS, Loving CL, Waide EH, Gauger PC, Dekkers JC, Tuggle CK, Vincent AL

Influenza A viruses (IAV) infect many host species, including humans and pigs. Severe combined immunodeficiency (SCID) is a condition characterized by a deficiency of T, B, and/or natural killer (NK) cells. Animal models of SCID have great value for biomedical research. Here, we evaluated the pathogenesis and the innate immune response to the 2009 H1N1 pandemic IAV (H1N1pdm09) using a recently identified line of naturally occurring SCID pigs deficient in T and B lymphocytes that still have functional NK cells. SCID pigs challenged with H1N1pdm09 showed milder lung pathology compared to the non-SCID heterozygous carrier pigs. Viral titers in the lungs and nasal swabs of challenged SCID pigs were significantly higher than in carrier pigs 7 days postinfection, despite higher levels of IL-1β and IFN-α in the lungs of SCID pigs. The lower levels of pulmonary pathology were associated with the T and B cell absence in response to infection. The higher viral titers, prolonged shedding, and delayed viral clearance indicated that innate immunity was insufficient for controlling IAV in pigs. This recently identified line of SCID pigs provides a valuable model to understand the immune mechanisms associated with influenza protection and recovery in a natural host.

PMID: 27988511 [PubMed - indexed for MEDLINE]

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